BALTIMORE -- The Boston Red Sox were coming off an exhausting night. They were missing their leading home run hitter and operating with a thin bullpen.
The Red Sox casually brushed aside those obstacles and cruised to another lopsided victory over the Baltimore Orioles.
Pedroia, Kevin Youkilis and Darnell McDonald had three RBIs apiece for the Red Sox, who have won 13 of 15. The run includes a 16-inning victory at Tampa Bay on Sunday night in which Boston mustered only five hits.
Showing very little signs of fatigue, the Red Sox banged out 16 hits in rolling to their seventh straight victory over Baltimore. Boston has outscored the Orioles 61-32 during that span.
The Red Sox checked into their Baltimore hotel around 6 in the morning, grabbed some sleep and put a whipping on the last-place Orioles.
"You guys are putting more into that than we are. If (we) had lost tonight, I wouldn't have used that as an excuse," Boston manager Terry Francona said. "Everybody is a little tired tonight, but you do what you're supposed to do."
It was the first meeting between the teams since the Red Sox recorded a heated four-game sweep at Fenway Park immediately before the All-Star break.
Boston designated hitter David Ortiz and Orioles closer Kevin Gregg began serving three-game suspensions for their part in a bench-clearing incident during that series. Both players were initially suspended for four games before appealing the punishment.
The Red Sox didn't miss a beat. Boston fell one run short of matching its season high and had six players with at least two hits, including Pedroia, whose 16-game hitting streak is one short of his career high.
"After getting a lot of guys on base and not being able to get the job done (Sunday), it felt good to come out tonight and score some runs," Reddick said.
After the Red Sox loaded the bases against Mike Gonzalez (1-2) in the eighth, Pedroia hit a tiebreaking two-run double off Jason Berken to make it 9-7. Youkilis added a two-run single, Carl Crawford singled in a run and McDonald capped the uprising with a three-run double.
Asked if it was difficult to play after such a quick turnaround, McDonald said: "It's not tough at all. This is what we get paid to do -- to play baseball. It was nice to come out and get a win after having such a long night."
Baltimore scored three runs in the eighth, but that just meant the Orioles lost when reaching double figures for the first time since Aug. 2, 2009. That was an 18-10 defeat against Boston.
"A couple guys on, we might have taken a roll at them in the ninth," Baltimore manager Buck Showalter said. "But they pitched a little bit better than we did tonight."
Dan Wheeler (2-1) got the win with 2 1/3 innings of no-hit relief for starter Tim Wakefield. His performance was particularly noteworthy because Matt Albers, Alfredo Aceves, Daniel Bard and Jonathan Papelbon pitched Sunday night.
"We didn't have Albers, didn't have Aceves, didn't have Bard," Francona said. "(Wheeler) comes in and shuts them down for a while. That's what gave us a chance. He threw the ball really well."
Wakefield gave up seven runs, three earned, and nine hits in 4 2/3 innings. He was undone by a particularly wicked knuckleball that produced a strikeout but resulted in a passed ball that fueled a five-run fifth inning that gave Baltimore a 7-6 lead.
Felix Pie opened the fifth by striking out, but he reached when the pitch eluded Saltalamacchia and went to the screen. Hardy, who signed a new three-year contract earlier in the day, hit a two-run homer and Jones drove a knuckleball an estimated 434 feet into the left-field stands.
Later in the inning, Nolan Reimold chased Wakefield with a two-run double.
Youkilis' RBI single tied it at 7 in the seventh.
Boston made it 5-2 in the fourth, scoring two unearned runs after Lee let a grounder to first base go through his legs. The miscue ended a run of six straight errorless games by Baltimore.
Reddick homered off the foul pole in the fifth for a 6-2 lead.
Crawford (back strain) was activated from the 15-day disabled list before the game and went 2-for-5. ... Lee's triple was his first since Aug. 17, 2009. ... RHP Mark Worrell, whose contract was purchased from Triple-A Norfolk before the game, became the 900th player to wear an Orioles uniform. He was charged with three runs without getting an out in the eighth. ... Wakefield's three strikeouts gave him 1,996 with Boston. Roger Clemens is the only player to have 2,000 strikeouts with the Red Sox.