The All-Star used both to give the Pirates their first winning streak in three weeks.
McCutchen went 4 for 4, including his second home run in as many nights, as Pittsburgh dropped the Washington Nationals 4-2 on Wednesday.
Brad Lincoln (2-0) earned the win in relief of starter Erik Bedard, who was lifted three pitches into the second inning due to back spasms. Joel Hanrahan survived a shaky ninth to pick up his sixth save as the Pirates won consecutive games for the first time since April 17-18.
Though McCutchen's eighth-inning blast gave the Pirates some breathing room, it was his daring dash from second to home on an infield single to cap Pittsburgh's three-run third inning that stoked his teammates.
The Pirates had runners on first and second with two outs when McCutchen took off on Casey McGehee's slow roller to shortstop. Washington's Ian Desmond scooped it up and thought about firing to first before pulling the ball down. Desmond then glanced at third, but McCutchen was already on his way to the plate. By the time Desmond got the ball out of his hands, it was too late.
"He hesitated a little bit and I guess that was just enough," McCutchen said. "It was one of those, might as well go and I went."
Desmond praised McCutchen's speed rather than blame his own indecision.
"I would say nine or 10 times out of 10 that runner stops and tries to dive back into third," Desmond said. "He saw that I fielded it and he looked at me and darted toward home."
Ross Detwiler (3-2) allowed three runs and seven hits with four strikeouts in six innings for Washington. Desmond had two hits and Xavier Nady and Chad Tracy knocked in runs for the Nationals, but they couldn't stop Washington from dropping its third straight.
"My guys are trying, pumped up to keep winning ballgames," Washington manager Davey Johnson said. "We're just not getting quality at-bats, that's all."
Washington had its chances to rally in both the eighth and ninth.
Hanrahan, who blew a save on Tuesday only to be bailed out by Rod Barajas' game-winning two-run homer, entered in the ninth and struggled again. He hit pinch-hitter Steve Lombardozziwith one out then gave up a double to Desmond.
In stepped heralded Washington rookie Bryce Harper, still looking for his first major league home run. He swung for the fences while falling behind 0-2 then popped meekly to shortstop.
Ryan Zimmerman followed and worked the count full before striking out on a 96 mph fastball from Hanrahan.
"I had a good pitch to hit, I just missed it," Zimmerman said. "(Hanrahan) throws hard; it's not easy to square someone up like that."
The victory gave the Pirates something they haven't had in a while: momentum. Save for a brief two-game slide in St. Louis last week, Pittsburgh has alternated wins and losses in each game.
The Pirates hoped Bedard would give them a boost. Instead the oft-injured left-hander was lifted after throwing a fastball to Adam LaRoche in the second inning. Bedard grabbed his side after letting the pitch go. He tried to stretch for manager Clint Hurdle before being sent to the dugout.
"I think it just jumped on him," Hurdle said.
Enter Lincoln, a spot starter turned long reliever. He gave up an unearned run, one hit and four strikeouts and one walk in three innings while dropping his ERA to 0.63.
"I had no time to think about getting into the game," Lincoln said. "You just go in there and give `em what you got."
Nady, making a start in right field in place of injured Jayson Werth, put Washington on the board with an RBI single in the fourth and Tracy's pinch-hit sacrifice fly in the seventh pulled the Nationals within 3-2.
Washington would get no closer, though the Nationals refused to blame their slide on a letdown following an emotional home series with Philadelphia last weekend.
"I think guys are frustrated, not like we're out of it by any means but guys are frustrated because they know what we can do," Desmond said. "We know we're a good offensive ballclub."
Injured Washington reliever Drew Storen could begin a throwing program by the end of the week. Storen hasn't pitched all season while recovering from bone chips in his right elbow. Johnson said he's hopeful Storen and closer Brad Lidge -- recovering from abdominal surgery -- will be making rehab appearances by the end of the month ... The series concludes on Thursday when Washington's Stephen Strasburg (2-0, 1.66 ERA) faces Pittsburgh's Kevin Correia (1-2, 3.38) ... Pittsburgh outfielder Alex Presley, mired in a 3 for 28 slump, didn't start for the second straight game while he works in the batting cage.