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TORONTO -- Coco Crisp hit two home runs and Yoenis Cespedes had a pair of RBI doubles, leading A.J. Griffin and the Oakland Athletics over the Toronto Blue Jays 16-0 on Wednesday night for their season-high seventh straight win.

It was the most-lopsided shutout loss ever for Toronto. Things got so out of hand that the Blue Jays used catcher Jeff Mathis to pitch the ninth inning, and he gave up two runs on an RBI double by Brandon Hicks and an RBI single by Brandon Moss.

Chris Carter homered and drove in three runs. He drew a bases-loaded walk from Ricky Romero during an eight-run second inning as Oakland improved to 16-2 in July.

Griffin (3-0) gave up three hits in six innings. The rookie struck out nine in winning his third straight start and leaving with a 2.25 ERA.

Romero (8-7) lasted only 1 1/3 innings in the shortest start of his career. He lost his sixth decision in a row.

Crisp hit a leadoff drive to right in the third and went deep to almost the same spot in the fifth, his first multihomer game of the season and the third of his career.

The A's posted their fifth 16-0 shutout in franchise history and their first since a lopsided win over San Francisco on June 26, 2005.

Jonny Gomes reached base four times for Oakland, now 10-1 since the All-Star break.

Mathis came into the game in the second after Toronto lost catcher J.P. Arencibia to a broken right hand after he was hit by Brandon Inge's foul tip. Arencibia stayed in the game until the half-inning ended, and is expected to miss six weeks.

Romero, who came in 4-0 with a 1.70 ERA in six career starts against the Athletics, allowed eight runs on four hits and six walks.

Already leading on Cespedes' RBI double in the first, Oakland broke it open in the second.

Left fielder Travis Snider's error on Crisp's single led to the first run, and Gomes followed with an RBI single. Josh Reddick added an RBI double and, after an intentional walk to Cespedes loaded the bases, Romero ended his night by walking Carter to force home a fifth run.

Inge greeted reliever Chad Beck with a two-run double, Derek Norris grounded a run-scoring single through the right side and Hicks capped the rally with an RBI groundout.

The eight runs matched Oakland's biggest inning of the season. The A's also scored eight in the second inning of a 12-1 win over Texas on June 4.

Crisp's two solo shots made it 11-0 before Carter hit a drive in the sixth off Drew Carpenter, his sixth.

Game notes

Reddick made the defensive play of the game, climbing the chain link fence in front of the visiting bullpen in right and hanging there to snag Snider's deep drive for the final out of the second. Toronto fans cheered what they thought was a home run and the stadium horn sounded briefly as Reddick dropped down and ran off the field. ... The sixth position player in Blue Jays' history to take the mound, Mathis also pitched an inning in a 14-3 loss to Texas on May 26. ... Toronto SS Yunel Escobar was scratched due to tightness in his back and replaced by Omar Vizquel. ... Tuesday's surgery on Blue Jays RHP Sergio Santos showed fraying of the labrum but no tear, manager John Farrell said. Santos will begin a throwing program in mid-December and should be ready in time for spring training. ... Toronto RHP Drew Hutchison (elbow) is scheduled to resume throwing July 27, six weeks after his initial injury. Hutchison is not expected back until September. ... Blue Jays RHP Brandon Morrow (strained left oblique) threw 30 pitches of live batting practice Wednesday and will make a two-inning rehab start at Class A Dunedin on Sunday.