Colon worked seven strong innings to win his sixth straight decision, Reddick homered and matched a career high with four hits, and the Oakland Athletics avoided a sweep with a 10-2 victory over the Seattle Mariners on Sunday.
"I did feel tired during the second inning and was just trying to find a way to get through it," Colon said. "All I can say is that was the best play. I felt, 'Wow' and was ready to get the next guys out."
That catch, with the bases loaded and two runs already in, helped Oakland's pitchers face the minimum 23 batters the rest of the way, with a pair of double plays erasing the lone baserunners.
"He made several good plays," A's manager Bob Melvin said. "That play probably had a lot to do with getting the momentum back and allowing Bartolo to get his second wind."
Seth Smith and Brandon Moss each homered and drove in two runs for the Athletics, who moved three games ahead of Texas in the AL West -- their largest lead since ending the 2006 season four games up. Josh Donaldson also went deep, and Yoenis Cespedes, Coco Crisp and John Jaso each drove in runs for Oakland.
"I had a feeling about it as I was running in and watching it sink," Reddick said. "I shoestringed it and was kind of lucky because the ball was moving."
Colon (9-2) allowed two runs on eight hits, did not walk a batter and struck out three to extend his home win streak to seven.
"Today could have gotten away from him early," Donaldson said. "Reddick made that nice catch and it kind of picked him up. Bartolo is a never-say-die guy anyway. You know he's going to come back and throw strikes."
Hisashi Iwakuma (7-2) lost for the first time since April 23, giving up four runs on a season high-tying eight hits. He also walked Jaso three times and struck out three. Iwakuma's streak of not allowing an earned run was stopped at 31 2/3 innings, second longest in Mariners' history to Mark Langston's 34-inning streak in 1988.
Endy Chavez had two hits and drove in two runs for the Mariners, who were looking for their first sweep of the season.
Michael Morse, Jason Bay and Mike Zunino each singled to open the second inning for Seattle. After Colon struck out Brendan Ryan, Chavez delivered a two-run single. Nick Franklin singled to reload the bases, but Colon got Kyle Seager and Kendrys Morales on short fly balls to limit the damage.
"That was a great play. Seager couldn't hit that ball any harder," Mariners' manager Eric Wedge said. "He hit it so hard it stayed for Reddick to get it. He's got a great arm too, so that was a tough one there."
Iwakuma allowed his first earned run since May 26 when the A's got to him in the fourth. Donaldson and Smith hit back-to-back doubles to open the inning and Reddick followed with an RBI single.
Cespedes and Moss each drove in a run in the fifth to make it 4-2.
Colon slammed the door on the Mariners after the second, retiring 11 straight before allowing Morse's single in the sixth. Colon induced a double play ball from Bay and then worked a perfect seventh.
"He didn't change a thing," Chavez said of Colon. "He kept throwing the same things, a sinker inside and a fastball outside for strikes."
Donaldson and Smith hit back-to-back home runs with one out in the seventh against Blake Beaven. Crisp later walked with the bases loaded and Jaso hit a sacrifice fly against Tom Wilhelmsen to make it 8-2.
Moss and Reddick each went deep in the ninth against Carter Capps.
Mariners LHP prospect Danny Hultzen (rotator cuff strain) remains at extended spring training. The former first-round draft pick last appeared in a game on April 19 with Triple-A Tacoma. Manager Eric Wedge said before the game that Hultzen would remain in Peoria while he continues to build arm strength. ... A's INF Jed Lowrie was given the day off as manager Bob Melvin continues to deal with the effects of Thursday's 18-inning game against the New York Yankees. ... Cespedes will likely return to the outfield when the A's open a four-game series at Texas on Monday. ... Colon threw 31 pitches in the second inning, the first time he's thrown 30 or more in an inning this year. ... INF Justin Smoak (strained right oblique) could return to the Mariners lineup as early as Monday night in Anaheim. ... The A's hit more than two home runs in a game at home for the first time this year. ... RHP Aaron Harang (3-6, 5.60 ERA) takes the mound for Seattle against the Los Angeles Angels on Monday. He threw a two-hit shutout in his last start. ... The A's will send RHP Dan Straily (4-2, 4.45) to the mound against the Rangers. He's 3-0 with a 2.21 ERA over his last five starts.