That didn't shake his confidence, though, and when he got another shot late with the game on the line, the touted rookie came through for Houston.
Springer singled home the winning run in the 11th inning to give the Astros a 5-4 victory over the Seattle Mariners.
Springer, called up from Triple-A on April 16, had an infield hit toward third after beginning the night 0 for 5 with four strikeouts in a game started by Seattle ace Felix Hernandez.
"It was obviously a sense of relief, I want to say," Springer said. "You obviously want to be big in that spot. I was able to slow down, and I was happy. I'll take it."
Astros manager Bo Porter hopes that the win in the team's last at-bat will help Springer take off at the plate.
"When you watch George, and even through his struggles tonight, there was never a doubt in his mind," Porter said. "He continues to battle and ends up being the guy at the plate with the bases loaded ... and ends up coming up with the big hit."
Hernandez allowed five hits and three runs -- two earned -- with six strikeouts in five innings while battling flu-like symptoms.
"I didn't know what we were going to get out of him," manager Lloyd McClendon said. "He was drained. He was sick yesterday. Very weak today. He did a great job for us and kept us in the ballgame."
Hernandez said it was really tough to pitch with the way he was feeling.
"I still feel bad," he said. "I still have to go out there and do my job."
Houston starter Brad Peacock gave up six hits and four runs in six innings. He struck out six and walked three.
Michael Saunders started the sixth with a bunt single and Cano drew a one-out walk before Corey Hart singled to load the bases. Seager's two-run double gave Seattle a 4-3 lead.
Springer had a chance to catch the ball in right field, but it bounced off his glove as he crashed into the fence near the bullpen. He was splayed on the ground as Fowler came over to retrieve the ball.
Seager singled with none out in the fifth before Zunino connected on his homer to the Crawford Boxes in left field to tie it at 2 with two outs.
Hernandez plunked Jason Castro in the fifth before Krauss' RBI single, on a ball that bounced right in front of the wall in right field, put Houston back on top 3-2. Krauss was thrown out trying to stretch the hit into a double.
Altuve had a bunt single to start the third before an infield single by Fowler. The Astros went up 1-0 when Castro reached on an error by center fielder Abraham Almonte.
Krauss' RBI single sent Fowler home to push the lead to 2-0.
Seattle RHP Hisashi Iwakuma (finger) is scheduled to come off the disabled list and make his season debut against left-hander Dallas Keuchel when the series continues Saturday. McClendon said Iwakuma will likely by limited to about 100 pitches. ... McClendon said he expects RHP Taijuan Walker (shoulder) and LHP James Paxton (back) to start throwing bullpens sometime in the next week. ... Houston signed left-handed reliever Tony Sipp. The Astros also optioned RHP Paul Clemens to Triple-A and transferred RHP Jesse Crain to the 60-day disabled list.