SAN DIEGO -- For a Padres team that's struggled to score all season, this was certainly a different feeling.
"There is a little bit of momentum that happens in the dugout, and quite honestly, we haven't had that much," manager Bud Black said.
Twice this season, the Padres have won with only one hit -- and San Francisco right-hander Tim Lincecum pitched a no-hitter against them last Wednesday.
But one night after managing just one hit in a 1-0 victory over the Reds, the Padres banged out a season-high 16. Every batter in the starting lineup had a hit.
"The guys did a good job of getting their pitches and not missing," said Smith, who had three hits.
Ian Kennedy (6-9) pitched six solid innings, giving up one run and seven hits with a walk and three strikeouts to get his first win in nearly a month. Kennedy, who improved to 4-1 in his career against the Reds, was 0-3 with a 6.08 ERA in his last four starts in June.
"I was getting ahead with my fastball and keeping it down and throwing my off-speed pitches for strikes," Kennedy said.
Quentin's two-run homer in a four-run seventh was the key blow as the Padres extended their lead to 7-1.
"That was a no-doubter," Smith said of Quentin's 416-foot drive. "It was long, loud and fun to watch."
Mike Leake, vying for his career-best fourth straight win, allowed three runs and 11 hits in 5 2/3 innings. In each of his previous two starts, Leake (6-7) gave up one run and four hits in eight innings.
"They found a lot of holes," Leake said. "They hit me and made me work at trying to keep the ball down."
San Diego had its highest run total since an 11-1 win over the Cubs on May 23.
The Padres got the game's final out when the original call was overturned on instant replay. Todd Frazier was originally ruled safe on a force play at second before Black challenged the call.
It marked the second time since expanded instant replay was instituted this season that a game ended with a call being reversed.
"The problem is replay is becoming a hot topic," Reds manager Bryan Price said. "We left the field angry several times and today's another one. You're castrated by the inability to talk to the umpires about the play."
Chase Headley put the Padres ahead 3-1 with an RBI single in the sixth to drive in Smith, who doubled to right field.
Smith hit his ninth homer leading off the first to give the Padres a 1-0 lead. It matched their hit total from the previous night and was San Diego's first homer since Tommy Medica had one on June 24.
"When a guy hits a leadoff bomb to start the game, that relieves a little pressure," Black said.
"It's awesome and you know you have at least a one-run cushion and it gives you a little more leeway," he said.
Quentin also doubled in the first inning, but was doubled off second base when he sprinted for third on an infield popup after forgetting how many outs there were.
After totaling just five runs in their previous five games, the Padres extended the lead to 2-0 when Kennedy got San Diego's third straight single.
The Reds pulled to 2-1 in the fifth when Frazier's two-out, broken-bat single to center drove in Zack Cozart. That snapped the Padres' scoreless streak at 21 innings.
Padres SS Everth Cabrera was a late scratch with a strained left hamstring. He'll be re-evaluated Friday, but could be headed to the disabled list. ... RHP Andrew Cashner (sore right shoulder) will resume throwing Wednesday after getting the OK from the team's medical staff. ... San Diego 2B Jedd Gyorko (plantar fasciitis) had his cast removed. ... Reds 1B Joey Votto was lifted for a pinch runner, an indication his left knee remains tender. "He is not running at full speed," Price said. ... Reds RHP Johnny Cueto (8-5, 1.88 ERA) faces RHP Tyson Ross (6-8, 3.18) in Wednesday afternoon's series finale.