It was his first trip to Chicago since signing with the Rockets in the offseason.
"Omer is a big-time player in the middle," Rockets coach Kevin McHale said. "Tonight he was blocking shots, getting rebounds and outletting the ball for us. He's got a big body and sets wide picks for us. This was a very good game for him."
Harden scored 26 points, and Lin added 20 points and 11 assists for Houston, which had all five starters score in double figures.
Houston has won six of seven.
The Rockets had been just 3-7 on the road entering Tuesday, but a strong second quarter turned the holiday matchup into a blowout. The Rockets outscored the Bulls 31-19 in the period to break open the game.
Lin capped a 14-2 run midway through the quarter with a drive and a layup to make it 55-34. He scored 12 in the second quarter, and Harden had 13.
Houston led 58-41 at halftime.
"We are a very young team but are continuing to learn and believe in our system," McHale said.
Houston entered the game tops in the league in scoring at 105.4 points per game, while Chicago allowed the third fewest in the league at 91.
Houston, though, was not slowed at all.
The Rockets pushed the pace and shot well against Chicago's defense. The Rockets outscored the Bulls 66-32 in the paint and 31-8 in transition. Their largest lead was 35 points.
The 120 points allowed and the 23-point loss were season worsts for the Bulls.
The Turkish-born Asik spent his first two years in the NBA with Chicago. He signed a three-year, $25 million offer sheet with the Rockets this summer that the Bulls did not match.
He entered the game averaging 10.6 points and 11.4 rebounds, and put together perhaps his best game of the season.
Asik received a round of applause when he was introduced at the beginning of the game, but the hospitality didn't last. He quickly heard jeers when he stepped to the free throw line early in the first quarter.
"I'm just happy we won the game," Asik said.
He added that he did not think much about his return to Chicago.
"He was great just rolling to the basket," Bulls center Joakim Noah said. "They played four out and one in, and he was able to get a lot of easy things around the rim."
Harden, fourth in the league in scoring, followed up two strong performances -- 37 points against Detroit and 45 against Atlanta -- with another strong game. He was 7-for-13 from the field and 11-for-13 from the free throw line.
Houston improved to 11-2 against the Eastern Conference.
The Bulls had won nine of 13 to climb into first place in the Eastern Conference's Central Division but were flat for the second consecutive game. Chicago lost 92-75 on Saturday in Atlanta.
Boos came down from the United Center crowd when Asik scored to make it 82-51 in the third quarter.
"If you are not right and don't have an edge, you are not going to win without the right amount of intensity," Bulls coach Tom Thibodeau said. "They completely outplayed us from the start."
Chicago cut the Houston lead to 100-85 with just less than eight minutes to play in the fourth quarter, but a 6-0 Rockets run ended the rally.
Both teams have quick turnarounds for Wednesday games. The Bulls travel to Indianapolis to play the Pacers, and the Rockets visit the Minnesota Timberwolves.
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