"It's business as usual," forward Chris Bosh said of the star guard's absence.
He's only slightly exaggerating as Miami improved to 11-1 in Wade's absence. He is expected back for Sunday's game at New York.
Bosh had 18 points and seven rebounds as the Heat completed a three-game season-series sweep of Charlotte. Miami led by 22 after three quarters and rested James, who also had five assists, the entire final period.
Miami bounced back after a disappointing 96-86 overtime loss at Chicago on Thursday night that likely ended the Heat's hopes of getting the No. 1 seed in the Eastern Conference playoffs.
"It was important for us to get better tonight and get a win," James said.
Derrick Brown had 21 points and nine rebounds to lead Charlotte, which lost its 15th straight. The Bobcats trailed 33-19 after the first quarter and got no closer than 15 points in the second half.
The absences from forced Miami to have its third different starting lineup in three games. Swingman James Jones (six points on 2-for-7 shooting) started for Wade, and center Joel Anthony replaced Haslem, who got his first start a night earlier at Chicago in place of Ronny Turiaf.
However, the injuries didn't ease Charlotte coach Paul Silas one bit.
"If Wade, Bosh, and LeBron were out then I'd be smiling," he said before the game.
The Bobcats were also short-handed, starting the game with just 10 players in uniform. Among the missing were forward Tyrus Thomas (right knee contusion), center DeSagana Diop (left Achilles), forward Corey Maggette (right Achilles), and forward Eduardo Najera (frontal bone fracture).
Then, forward D.J. White was hit in the head in the second quarter and the resulting headache meant he didn't play in the second half.
"I think we played hard," Brown said. "We're short-handed right now. This team just keeps on playing through adversity. Obviously, it's bad but we need to continue to play as hard as we can to get ready for the future."
The Bobcats, a league-worst 7-51, are in danger of not reaching double-digit victories in this lockout-shortened 66-game season. Charlotte needs three victories in the final eight games.
Miami made quick work of the Bobcats. The Heat took a 58-39 halftime lead by shooting 58.5 percent from the field and holding Charlotte to 38.5 percent.
Charlotte didn't offer much resistance.
The Heat reserves, outscored 47-7 by their Chicago counterparts a night earlier, finished with 44 points and 17 rebounds against the Bobcats. Center Dexter Pittman had a career-best 16 points.
Miami is in the midst of playing five games in seven days. It hosted Boston (Tuesday), visited Chicago (Thursday), hosted Charlotte (Friday) and visits New York (Sunday) and New Jersey (Monday). ... James scored in double digits for the 136th consecutive game with the Heat. The franchise record is 148 by Wade. James has scored in double digits for 414 consecutive career games. ... Henderson has scored in double figures in 14 of his past 18 games.