Ray Allen, making Miami debut, had 10 points and five assists in 27 minutes.
Wade is expected to travel with the Heat for a seven-day trip to China that will include exhibition games against the Los Angeles Clippers on Thursday and next Sunday.
James had six rebounds and a game-high six assists in 24 minutes.
Indiana's strong showing against the Raptors revealed that Paul George has fully returned from his devastating leg injury.
For the first time in 15 years, the Toronto Raptors advanced to the second round of the playoffs, holding off the Pacers in Game 7.
Did you know Klay Thompson's 21 3-pointers over his previous three games breaks Steph Curry's postseason record for 3-pointers over a three-game stretch?