Kyrie Irving, last season's Rookie of the Year, snapped out of his preseason shooting slump with 22 points for the Cavaliers (3-2), who came from behind after blowing a 14-point third-quarter lead.
Glen Davis scored 27 points to lead Orlando (0-3).
Irving shot just .239 (11 of 46) from the field in Cleveland's first four preseason games, but he scored nine straight to spark a 21-6 run that put the Cavaliers ahead 31-19 with 29.6 seconds left in the first half. He finished the first quarter with 11 points and the first half with 18, two more than his previous preseason single-game high of 16.
He finished an efficient 5 for 8 from the field and 11 for 11 on free throws.
The Chicago Bulls selected Michigan State forward Denzel Valentine with the No. 14 overall pick of the 2016 NBA draft on Thursday night.
Amin Elhassan and Myron Medcalf break down Taurean Prince heading to the Hawks.
The Phoenix Suns selected Greek center Georgios Papagiannis with the No. 13 overall pick of the 2016 NBA draft on Thursday night.