Kyrie Irving, last season's Rookie of the Year, snapped out of his preseason shooting slump with 22 points for the Cavaliers (3-2), who came from behind after blowing a 14-point third-quarter lead.
Glen Davis scored 27 points to lead Orlando (0-3).
Irving shot just .239 (11 of 46) from the field in Cleveland's first four preseason games, but he scored nine straight to spark a 21-6 run that put the Cavaliers ahead 31-19 with 29.6 seconds left in the first half. He finished the first quarter with 11 points and the first half with 18, two more than his previous preseason single-game high of 16.
He finished an efficient 5 for 8 from the field and 11 for 11 on free throws.