Lillard scored nine consecutive points in the period as the Blazers pulled away after trailing by a point at halftime. Nicolas Batum scored 14 points and Robin Lopez added nine points and 10 rebounds as Portland built a 17-point lead with less than 10 minutes left in the game.
The Los Angeles bench, led by Darren Collison, cut the deficit to four points, but Portland finished the game on a 10-2 run. Collison led all scorers with 31 points and added six assists.
Blake Griffin was the only other Clippers player to score in double digits, finishing with 18 points and six rebounds in 25 minutes. Chris Paul added seven points and four assists in 30 minutes.