Florida Gulf Coast took a commanding lead early opening the game on a 20-5 run. The Eagles led at halftime 34-24.
Samford (1-7) would get within 8 points in the second half, 34-26, but the Eagles would push the lead to double figures for the rest of the game.
Florida Gulf Coast shot 57.1 percent (16 for 28) in the second half to blow out Samford.
The Eagles dominated the Bulldogs on the glass, outrebounding Samford 44-25 for the game.
Raijon Kelly led the Bulldogs with 13 points.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.