Tyrus McGee had 15 points off the bench for the Cyclones (11-4, 1-1 Big 12), who bounced back from a heartbreaking loss at No. 6 Kansas by pounding the struggling Longhorns (8-8, 0-3).
Iowa State built an 11-point halftime lead and maintained a comfortable edge the rest of the way in beating Texas for just the second time in 11 tries.
Johnathan Holmes and Julien Lewis each had 15 points to lead the Longhorns.
Texas star Sheldon McClellan, the team's leading scorer at 15.2 points per game, played just one scoreless minute.
Purdue coach Matt Painter says players haven't used the fifth-year graduate transfer rule for its true intent.
The 2017 recruiting class is short on point guards, with Trevon Duval leading only eight prospects from the ESPN 60 who are still available.
The dust has settled after players made their NBA draft decisions. Which college teams won? Which lost? Well, Villanova is pretty happy. USC, meanwhile, might not be as thrilled.