Melvin Ejim had 13 points and 13 rebounds for the Cyclones (19-8, 9-5 Big 12), who tuned up for Monday's home game with Kansas by outscoring the Red Raiders 50-37 in the second half.
The Cyclones stretched their lead to double digits, 50-39, with 13:52 to go and led by at least 10 the rest of the way. Iowa State went ahead by as many as 28 points in cruising to its 22nd straight home win.
Josh Gray had a game-high 20 points for Texas Tech (9-16, 2-12), which has lost eight in a row. Texas Tech handed Iowa State its only bad loss so far, stunning the Cyclones 56-51 in Lubbock last month. The Red Raiders haven't won since.
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Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.