Melvin Ejim had 13 points and 13 rebounds for the Cyclones (19-8, 9-5 Big 12), who tuned up for Monday's home game with Kansas by outscoring the Red Raiders 50-37 in the second half.
The Cyclones stretched their lead to double digits, 50-39, with 13:52 to go and led by at least 10 the rest of the way. Iowa State went ahead by as many as 28 points in cruising to its 22nd straight home win.
Josh Gray had a game-high 20 points for Texas Tech (9-16, 2-12), which has lost eight in a row. Texas Tech handed Iowa State its only bad loss so far, stunning the Cyclones 56-51 in Lubbock last month. The Red Raiders haven't won since.
Nike Youth Iowa State Cyclones Cardinal Basketball Practice T-ShirtShop
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.