HARTFORD, Conn. -- Stanford finally has a signature win. UConn has its first loss.
Chasson Randle scored 22 points, and the Cardinal upset the 10th-ranked Huskies 53-51 on Wednesday night.
It was the first win for Stanford (8-2) against a top-25 team away from Palo Alto since the 2008 NCAA tournament. The Cardinal's previous seven wins this season came over teams that were a combined 32-41.
"I think it's an important win for our conference," Stanford coach Johnny Dawkins said, referring to the Pac-12. "A number of teams have had some real signature wins, and I'm just happy that we were able to have one as well."
DeAndre Daniels had 15 points for UConn (9-1), which was 6-of-10 from behind the arc in the first half and 0-for-12 in the second.
Randle's jump shot with 3 1/2 minutes left gave the Cardinal a 52-49 lead. The Huskies pulled within a point when Daniels tipped in a missed 3-point attempt by Niels Giffey.
But Shabazz Napier missed three shots in the final 40 seconds with a chance to put the Huskies ahead. He gave up an opportunity on UConn's final possession, passing the ball to Omar Calhoun, whose 3-pointer from the right wing bounced off the rim.
"I felt like Omar was the most open guy at the time," Napier said. "I felt like it was going to go in, and I bet he did, too."
Napier, who finished with 12 points and eight assists, missed two 3-pointers on a key possession with the Huskies trailing 52-51. Stanford got the ball back with 28 seconds left after a scrum underneath the basket.
Napier fouled Huestis on the inbounds play, and he hit one of two free throws.
Napier, who beat Florida with a jumper at the buzzer earlier this month, missed another shot with 8 seconds left, forcing UConn to foul again.
He got the ball back on a rebound after Huestis missed another free throw. He dribbled down the court, but instead of trying a contested shot, he passed to Calhoun.
UConn led by 10 points at halftime and pushed the lead to 43-30 before consecutive 3-pointers by Anthony Brown and Randle. That started a 14-0 run by the Cardinal, who used a stifling zone defense to hold the Huskies without a field goal for more than six minutes. The Huskies were just 5-of-31 from the field in the second half.
"It was just a matter of us being aggressive on the defensive end," Randle said. "Just being active, getting our hands moving, getting our feet moving, and getting our feet moving and just hustling."
A driving basket and free throw by Randle gave Stanford its first lead of the second half at 44-43.
"Our guys really stepped up on the defensive end," Dawkins said.
Napier's jumper from the lane put UConn back on top 45-44 with just more than 10 minutes left, and the teams went back and forth.
The Huskies closed the half on a 14-3 run that ended when Napier stole the ball from Randle and found Lasan Kromah ahead of the field for an easy layup just before buzzer.
UConn went in shooting better than 46 percent from beyond the arc, with five players having made 10 or more 3-pointers.
The loss snapped a 54-game home winning streak against nonconference opponents that dated to 2007.
Connecticut was coming off its annual hiatus for final exams. The Huskies had not played in 12 days, since a 95-68 win over Maine, a game in which UConn hit 14 3-pointers.
Stanford ended a 13-day break Saturday with a 27-point win over UC Davis.
UConn plays at Washington, another Pac-12 team, on Saturday. UConn has dominated that conference; going into Wednesday, the Huskies were 17-2 and had won 13 straight since falling to UCLA in the 1995 NCAA West Regional championship.
Stanford's two losses came early in the season, at home to BYU and to Pittsburgh in the Legends Classic on Nov. 26 in Brooklyn. The Cardinal return to the Barclays Center to face Michigan on Saturday.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.