The Wolverines (13-3, 3-1 Big Ten) have won eight of nine games, a stretch started by handing No. 2 Duke its only loss.
The Hawkeyes (11-6, 1-3) didn't have a double-digit scorer until Matt Gatens made a 3-point shot with 2 minutes left. Iowa lost for the fourth time in six games, dating to a 17-point loss to Drake.
Michigan was in control from the start, scoring the first two baskets en route to a 15-4 lead. The Wolverines led 32-16 at halftime and didn't have any trouble keeping its big lead.
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Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.