John Shurna hit a fallaway 3-pointer with 3.3 seconds left to give the Wildcats the win. The freshman scored 9 points.
Moore hit seven 3-pointers and Coble went 10-of-14 for the Wildcats (14-10, 5-8 Big Ten), who took control of the game with an 18-3 run early in the second half. Northwestern had lost 11 in a row to Ohio State going back to 1998.
The Buckeyes (17-7, 7-6) lost their second straight, falling into a three-way tie for fifth place in the conference.
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Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.