Leading 39-36 with 18:49 left, the Great Danes (4-6) used a 20-7 run to pull away. Albany shot 57.1 percent (16-for-28) from the field in the second half while the Quakers were 34.8 percent (8-for-23).
Penn (0-6) which won't play again at home until Jan. 13 against Temple, is off to its worst start since beginning the 2000-01 season 0-8.
Mike Johnson added 15 points and seven assists for Albany.
Albany won 73-63 last year in the only other meeting between the two schools.
Who are the winners and losers from the 2016 NBA draft? Chad Ford gives his early ratings.
Former Vanderbilt guard Wade Baldwin IV becomes the 6th Commodore to be selected in the 1st round of the NBA Draft.
Former No. 1 pick Allen Iverson shares his advice with Ben Simmons, the newest member of the 76ers.