The Saints came in with the longest winning streak in the nation, but were stung by a tenacious Purple Eagles defense that forced 16 turnovers and had nine steals.
Kashief Edwards added a career-high 20 points, and Bilal Benn finished with 15 for Niagara (14-13, 7-8 Metro Atlantic Athletic Conference), which lost to Siena in the MAAC championship game last March.
Down by one point with 15 minutes left in the second half, the Purple Eagles pulled away with a 21-3 run that was capped by Demetrius Williamson's 3 with 9:54 to go that made it 70-53.
While the Wolverines had some turnover to their roster, they still could have a leg up in a conference that lost a lot of star power.
Mike Krzyzewski says he has good reason to be excited for next season thanks to a combination of Duke's incoming freshmen and a core of experienced upperclassmen.
Georgia guard Juwan Parker has been awarded a medical redshirt, leaving him with two years of eligibility, after missing the 2015-16 season with a partially torn Achilles tendon.