Jake Anderson added 10 points, 12 rebounds and five assists for the Cyclones, who built a 23-point lead in the first half and were never threatened after that.
Iowa State (2-0) trailed 9-7, then promptly erased any hopes the Hornets (0-2) had of staying close by scoring 29 of the next 33 points to take control.
The Cyclones had runs of 12-0 and 10-0 during that stretch and limited Alabama State to one field goal over a 10-minute span. Ahead 41-22 at halftime, Iowa State started the second half with an 11-2 burst and coasted from there.
Stephawn Brown led Alabama State with eight points.
Nike Youth Iowa State Cyclones Cardinal Basketball Practice T-ShirtShop
High school junior Zach Brown, a 7-footer from Miami, has rescinded his commitment to UConn, sources told ESPN.
Reserve center Akolda Manyang has been charged with felony aggravated assault after being accused of punching a man in the face without provocation.
Should the 76ers take Ben Simmons No. 1? What if they get the Lakers' pick, too? And how does the rest of the top 10 shake out? Our Insiders run their latest mock draft, with Philly on the clock.