Jake Anderson added 10 points, 12 rebounds and five assists for the Cyclones, who built a 23-point lead in the first half and were never threatened after that.
Iowa State (2-0) trailed 9-7, then promptly erased any hopes the Hornets (0-2) had of staying close by scoring 29 of the next 33 points to take control.
The Cyclones had runs of 12-0 and 10-0 during that stretch and limited Alabama State to one field goal over a 10-minute span. Ahead 41-22 at halftime, Iowa State started the second half with an 11-2 burst and coasted from there.
Stephawn Brown led Alabama State with eight points.
Nike Youth Iowa State Cyclones Cardinal Basketball Practice T-ShirtShop
The Big East has joined the ACC, Atlantic 10 and Colonial Athletic Association in forming a men's basketball officiating alliance.
Nebraska guard Andrew White, who averaged 16.6 points and 5.9 rebounds per game last season, will transfer from the program and is eligible immediately. What else is on Dickie V's mind this week?
The Cavaliers bring in a top-10 class of four incoming freshmen, so the Class of 2017 will be a small one. Coach Tony Bennett is aiming high.