The Monarchs (7-2) started the game with an 18-0 run and maintained a double-digit lead the rest of the way.
The Hawks (2-6) did not make their first basket until a Lyvann Obame Obame layup with 12:36 to go in the first half.
Old Dominion outrebounded the Hawks 64-28, setting a Ted Constant Center record for most rebounds, and scored 24 second-chance points.
Keyon Carter added 13 points and nine rebounds for the Monarchs and Chris Cooper tied the arena record with a career-high 16 rebounds. Old Dominion's Alex Loughton also had 16 against George Mason in 2004.
Obame Obame and Dishawn Bradshaw scored eight points each for Maryland-Eastern Shore, which shot only 25.9 percent from the field (15 of 58).
Reggie Witherspoon, who spent more than 13 seasons coaching at Buffalo, is returning to the city to coach Canisius College.
North Carolina Hall of Fame men's basketball coach Roy Williams is recovering from knee-replacement surgery.
Sparkling facilities are one thing, but Tim Miles needs to regain the momentum of Nebraska's 2014 run to the NCAAs if it is to play with the big boys.
|South Carolina State||12-4||1||19-15|
|North Carolina Central||7-9||6||13-19|
|North Carolina A&T||7-9||6||10-22|
|Texas San Antonio||3-15||13||5-27|