Dwight Powell had 14 points and 12 rebounds for the Cardinal (2-0), who opened the season with a victory over San Francisco on Friday night.
D.J. Seeley and Sammy Yeager scored 16 points each for the Titans, who tipped off their season with assistant coach Julius Hicks at the helm in place of interim coach Andy Newman, who is serving a two-game suspension for secondary NCAA rules violations.
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Devin Williams' decision last month to sign with an agent and enter the NBA draft has left West Virginia in a tough spot.
Florida State's student government has passed a resolution discouraging Seminoles fans from wearing Native American headdresses at games.
The second annual Gavitt Tipoff Games, eight games between members of the Big East and Big Ten to be played Nov. 14-18, will feature Villanova at Purdue in the opener.