The Catamounts (2-1), coming off a 67-49 loss at No. 23 Connecticut, broke open a 20-20 game with an 11-2 run in the last 5:56 of the first half.
The Huskies (2-1), whose two wins this season against Boston University and Princeton came on buzzer beaters, closed the gap to three, at 43-40 with 11:05 remaining, but could get no closer.
Northeastern's Joel Smith, who hit the game-winning basket to beat the Catamounts 53-51 last season, poured in 25 points. He was 9-of-17 from the field and made 5 of 7 from long range.
The Catamounts held Quincy Ford, who came in leading the Huskies in scoring at 19 points per game, to seven points on 3-of-10 shooting.
Donnie Tyndall is appealing the 10-year show-cause penalty that was handed down by the NCAA in April for violations stemming from his time as men's basketball coach at Southern Mississippi.
Top-50 prospect Jaylen Nowell committed to Washington on Wednesday. Nowell, a shooting guard, is No. 45 on the ESPN 100.
Mitchell Robinson, the No. 15 player in the country in the Class of 2017, has committed to Western Kentucky.