The Catamounts (2-1), coming off a 67-49 loss at No. 23 Connecticut, broke open a 20-20 game with an 11-2 run in the last 5:56 of the first half.
The Huskies (2-1), whose two wins this season against Boston University and Princeton came on buzzer beaters, closed the gap to three, at 43-40 with 11:05 remaining, but could get no closer.
Northeastern's Joel Smith, who hit the game-winning basket to beat the Catamounts 53-51 last season, poured in 25 points. He was 9-of-17 from the field and made 5 of 7 from long range.
The Catamounts held Quincy Ford, who came in leading the Huskies in scoring at 19 points per game, to seven points on 3-of-10 shooting.
The dust has settled after players made their NBA draft decisions. Which college teams won? Which lost? Well, Villanova is pretty happy. USC, meanwhile, might not be as thrilled.
The 2017 recruiting class is short on point guards, with Trevon Duval leading only eight prospects from the ESPN 60 who are still available.
ESPN college basketball reporter Andy Katz looks into the two decommitments from the NBA draft and what they're looking forward to.