Kevin Gray had 10 points and eight rebounds to lead the Huskies (1-2), who dropped road games at Nebraska-Omaha and Valparaiso.
The Eagles (2-6), who play in NAIA Division II, jumped out to a 20-12 lead. NIU answered by running off 15 straight points and eventually led 39-32 at halftime.
It was the first meeting between the schools.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.