Kevin Gray had 10 points and eight rebounds to lead the Huskies (1-2), who dropped road games at Nebraska-Omaha and Valparaiso.
The Eagles (2-6), who play in NAIA Division II, jumped out to a 20-12 lead. NIU answered by running off 15 straight points and eventually led 39-32 at halftime.
It was the first meeting between the schools.
High school junior Zach Brown, a 7-footer from Miami, has rescinded his commitment to UConn, sources told ESPN.
Reserve center Akolda Manyang has been charged with felony aggravated assault after being accused of punching a man in the face without provocation.
ESPN college basketball reporter Andy Katz discusses the need for the Pac-12 putting in place rules on that would prohibit storming the court after a win.