Jorden Page and James Walker III added 12 points apiece for the Gaels (3-0), who led 37-33 at intermission before coming out of the locker room with a 16-3 run. Waldow had six points during the outburst.
Saint Mary's shot 64.3 percent (18 for 28) from the floor in the second half.
Justin Crosgile had 13 points and five assists for the Eagles (0-3).
Matthew Dellavedova had nine points, eight assists and six rebounds for Saint Mary's.
Holt made all three of his 3-point attempts, and Walker was 3 of 5 from behind the arc.
Jalen Rose and David Jacoby announce their choices for sleepers in the 2016 NBA Draft.
Daryl Gross, who spent a decade as Syracuse's athletic director, will start as Division II Cal State-Los Angeles' AD in July.
Utah forward Brekkott Chapman, who averaged 4.4 points and 2.8 rebounds last season, has transferred to Weber State, coach Randy Rahe announced Wednesday.