Melvin Ejim contributed eight points and 10 rebounds for the Cyclones (4-0), who put the Aggies away with a big run late in the first half after a terrible start.
Unchallenged so far, Iowa State's competition will crank up several notches when it meets No. 22 Cincinnati on Friday in Las Vegas. The Cyclones have won their games by an average of 32.5 points
Jean Louisme led North Carolina A&T (1-4) with 11 points.