Sampson, who entered the game averaging 6.7 points and seven rebounds, also added 17 points. Kemp, who scored nine of his points from the free-throw line, grabbed 11 rebounds for the Pirates (4-0).
Appalachian State (1-3) scored the game's first four points and led 6-2 after Nathan Healy hit a jumper. But East Carolina used a 14-4 run to go ahead 16-10 with 14:29 left in the first half.
Appalachian State cut the deficit to 23-22 later in the half but would not get any closer as East Carolina took a 38-33 advantage into halftime and never led by less than four in the second half.
Jay Canty had 25 points and Healy added 24 points and 10 rebounds for Appalachian State.
We have changes at the top of the draft and a shakeup in the lottery, with teams starting to make their final decisions. Get the latest in Chad Ford's Mock Draft 9.0.
Duke freshman point guard Derryck Thornton Jr. is transferring to USC, his father announced on Friday to Scout.com.
NBA draft prospect Kris Dunn is excited to see Game 7 between the Cavaliers and the Warriors, he breaks down the constant comparison between LeBron James and Steph Curry and looks forward to playing with or against some of these guys next season.