Santa Clara (5-0) remained unbeaten by hitting 51 percent of its shots and converting 17 of 21 free-throw attempts.
Raymond Cowels III scored 12 points for Santa Clara, hitting four 3-point shots.
Eastern Washington (1-5) had a 27-19 scoring advantage off the bench, but could not remain in contention.
Collin Chiverton scored 19 points, including 4-of-8 shooting from 3-point range.
Eastern Washington had a 39-29 rebounding advantage, getting a game-high eight from Justin Crogsile.
Hal "King" Lear, a Temple basketball star during the 1950s, died Saturday at his White Plains, New York home.
Sebastien Bellin's friend Chris Young joins Ryan Smith on Outside the Lines to discuss his friend's bravery, courage and strength after surviving the Brussels bombings in March.
Andrew White III is leaving the Nebraska men's basketball team and will play elsewhere for his final college season.