Sam Mader scored 15 points for the Huskies (1-4), who shot just 32.7 percent (16 of 49) from the floor.
Northern Illinois trailed 27-19 at the break but cut the deficit to five points midway through the second half. But Humes scored five points and Talton four during a 10-2 run that gave Illinois-Chicago a 48-35 cushion with 6:52 remaining, and the Huskies got no closer than seven points the rest of the way.
Humes shot 7 of 8 from the field, with two 3-pointers.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.