Sam Mader scored 15 points for the Huskies (1-4), who shot just 32.7 percent (16 of 49) from the floor.
Northern Illinois trailed 27-19 at the break but cut the deficit to five points midway through the second half. But Humes scored five points and Talton four during a 10-2 run that gave Illinois-Chicago a 48-35 cushion with 6:52 remaining, and the Huskies got no closer than seven points the rest of the way.
Humes shot 7 of 8 from the field, with two 3-pointers.
Kentucky coach John Calipari on Thursday apologized to Rick Pitino if the Louisville coach took his recent comment about scandals on campus wrong.
College basketball coaches across the country will hit the recruiting trail hard in July to target the Class of 2017's top prospects. Which players are the nation's top programs targeting?
Sport Science examines Ben Simmons' max vertical and passing ability, as well as concerns about his jump shot.