Sam Mader scored 15 points for the Huskies (1-4), who shot just 32.7 percent (16 of 49) from the floor.
Northern Illinois trailed 27-19 at the break but cut the deficit to five points midway through the second half. But Humes scored five points and Talton four during a 10-2 run that gave Illinois-Chicago a 48-35 cushion with 6:52 remaining, and the Huskies got no closer than seven points the rest of the way.
Humes shot 7 of 8 from the field, with two 3-pointers.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.