After the Cougars (4-2) led 66-52 with 5:34 to play, the Buccaneers (2-4) reeled off 12 consecutive points. Saah Nimley and Arlon Harper, who finished with 20 points apiece, scored 10 of the Bucs' points in that run.
Harper buried a 3-pointer to make it a one-point game, 68-67, with 41 seconds left after Lawrence hit two free throws for the Cougars. Harper was unsuccessful on his next two 3-point tries, however, as Lawrence secured the game for College of Charleston with four free throws in the final 31 seconds.
The teams played at Charleston Southern's 881-seat Buccaneer Field House for the first time since 1992. Games hosted by Charleston Southern in the rivalry since then were played at the larger North Charleston Coliseum.