Florida Gulf Coast took a commanding lead early opening the game on a 20-5 run. The Eagles led at halftime 34-24.
Samford (1-7) would get within 8 points in the second half, 34-26, but the Eagles would push the lead to double figures for the rest of the game.
Florida Gulf Coast shot 57.1 percent (16 for 28) in the second half to blow out Samford.
The Eagles dominated the Bulldogs on the glass, outrebounding Samford 44-25 for the game.
Raijon Kelly led the Bulldogs with 13 points.
Forward Kennedy Meeks, who has averaged 9.4 points and 6.5 rebounds at North Carolina, has pulled out of the NBA draft and will return to the Tar Heels.
Cal big man Ivan Rabb could have been selected in the top 10 of the NBA draft. Instead, he's returning to Berkeley to make himself, and the Golden Bears, stronger.
Devin Williams' decision last month to sign with an agent and enter the NBA draft has left West Virginia in a tough spot.