The Rattlers (1-6) were led by Reggie Lewis with 13 points.
North Florida opened the second half with a 7-2 spurt for a 46-32 lead on David Jeune's layup 1:42 in and pushed it 59-36 on Wallace's layup midway through the half.
The Ospreys' lead never dipped below 19 points from there.
Florida A&M made the first bucket, but when North Florida's Cameron Naylor made two foul shots, the Ospreys led 18-8 with 12:50 left. North Florida maintained at least an eight-point lead and made it 39-23 on Charles McRoy's dunk with 1:45 left.
The Rattlers cut it to 39-30 at halftime.
Utah forward Brekkott Chapman, who averaged 4.4 points and 2.8 rebounds last season, has transferred to Weber State, coach Randy Rahe announced Wednesday.
Former LSU forward Ben Simmons joins The Paul Finebaum Show to talk about the prospect of being selected first in the NBA Draft.
Former Kentucky guard Jamal Murray joins The Paul Finebaum Show to discuss his mindset on the eve of the NBA Draft,
|South Carolina State||12-4||1||19-15|
|North Carolina Central||7-9||6||13-19|
|North Carolina A&T||7-9||6||10-22|