The Rattlers (1-6) were led by Reggie Lewis with 13 points.
North Florida opened the second half with a 7-2 spurt for a 46-32 lead on David Jeune's layup 1:42 in and pushed it 59-36 on Wallace's layup midway through the half.
The Ospreys' lead never dipped below 19 points from there.
Florida A&M made the first bucket, but when North Florida's Cameron Naylor made two foul shots, the Ospreys led 18-8 with 12:50 left. North Florida maintained at least an eight-point lead and made it 39-23 on Charles McRoy's dunk with 1:45 left.
The Rattlers cut it to 39-30 at halftime.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.
|South Carolina State||12-4||1||19-15|
|North Carolina Central||7-9||6||13-19|
|North Carolina A&T||7-9||6||10-22|