After Fairleigh Dickinson scored the opening basket, the Mountain Hawks (6-2) got the next 23 points and led by as many as 33 before closing the first half with a 46-17 lead.
McCollum scored 12 points in the half, when Lehigh shot 61.5 percent (16 of 26) to the Knights' 25 percent (5 of 20).
The Mountain Hawks shot even better in the second half, when Cvrkalj scored 15 of his points, making 22 of 34 (64.7 percent).
Gabe Knutson added 16 points for Lehigh, who earned coach Brett Reed his 100th win in his sixth season. At 100-65, he's the fastest in the Patriot League to reach that mark.
Lonnie Robinson scored 21 points for the Knights (3-4).
There's nothing to suggest the Jayhawks won't end up atop the Big 12 for a 13th season in a row. But what about a return to the Final Four?
Colorado State graduate transfer John Gillon has chosen Syracuse, giving the Orange a potential starter at point guard entering the 2016-17 season.
DeSean Murray, who averaged 20.2 points as a sophomore at Presbyterian, will transfer to Auburn to play for coach Bruce Pearl.