After Fairleigh Dickinson scored the opening basket, the Mountain Hawks (6-2) got the next 23 points and led by as many as 33 before closing the first half with a 46-17 lead.
McCollum scored 12 points in the half, when Lehigh shot 61.5 percent (16 of 26) to the Knights' 25 percent (5 of 20).
The Mountain Hawks shot even better in the second half, when Cvrkalj scored 15 of his points, making 22 of 34 (64.7 percent).
Gabe Knutson added 16 points for Lehigh, who earned coach Brett Reed his 100th win in his sixth season. At 100-65, he's the fastest in the Patriot League to reach that mark.
Lonnie Robinson scored 21 points for the Knights (3-4).
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.