Melvin Ejim chipped in with 14 points and 12 rebounds for the Cyclones (6-2), who've won two in a row ahead of Friday's showdown in Iowa City with the rival Hawkeyes.
Iowa State pushed a slim halftime lead to 62-46 early in the second half and went on a late 15-4 run to put the Eagles out of reach.
Chase Fieler had a game-high 18 points to lead Florida Gulf Coast (6-4), which had won two in a row.
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Andy Katz breaks down the likelihood of Villanova, Syracuse, North Carolina or Oklahoma making a run to the Final Four next season.
Florida State has announced that Xavier Rathan-Mayes will return to the court for his junior season. The 6-foot-4 guard declared for the NBA draft last month but did not hire an agent.
Virginia coach Tony Bennett takes the ACC Fast Break with Dino Gaudio by answering questions like who the best Tony Bennett is and what other sport he'd like to coach.