Melvin Ejim chipped in with 14 points and 12 rebounds for the Cyclones (6-2), who've won two in a row ahead of Friday's showdown in Iowa City with the rival Hawkeyes.
Iowa State pushed a slim halftime lead to 62-46 early in the second half and went on a late 15-4 run to put the Eagles out of reach.
Chase Fieler had a game-high 18 points to lead Florida Gulf Coast (6-4), which had won two in a row.
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