Melvin Ejim chipped in with 14 points and 12 rebounds for the Cyclones (6-2), who've won two in a row ahead of Friday's showdown in Iowa City with the rival Hawkeyes.
Iowa State pushed a slim halftime lead to 62-46 early in the second half and went on a late 15-4 run to put the Eagles out of reach.
Chase Fieler had a game-high 18 points to lead Florida Gulf Coast (6-4), which had won two in a row.
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Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.