Taran Buie led Hofstra (3-6) with 16 points.
After trailing 24-19 at halftime, Wagner (3-4) opened the second half with a 14-5 run, taking a 34-29 lead on Orlando Parker's three-point play with 11:38 left. Taran Buie's three-point play and 3-point shot pulled Hofstra to 36-35 at the 10:16 mark. Parker made a pair of free-throws to lead 38-35, and the Pride's Matt Grogan's free throw was the only point for the next 4:58.
Buie's foul shots with 2:56 left closed the gap to 44-41, but Wagner's Kenneth Ortiz made two baskets and two free throws to put the game away for the Seahawks, who won their second game in a row against the Pride.
Hofstra, 8 of 19 at the foul line, lost its fourth in a row.
The Pride played their second straight game without four players -- sophomore Shaquille Stokes and freshmen Kentrell Washington, Jimmy Hall and Dallas Anglin -- who were suspended from all university activities following their arrests last Friday on dormitory burglary charges.
Charles Matthews, who spent his freshman season at Kentucky, has picked Michigan as his transfer school, according to a source.
Chad Ford and Jeff Goodman offer their opinions on the surprises they're expecting at the NBA draft, with Ford believing there will be a lot of trade activity while Goodman thinks people will be surprised by potential draft spot of Marquese Chriss.
Louisville coach Rick Pitino said he doesn't "have time to figure out what" Kentucky coach John Calipari meant in recent comments that appeared to be a jab at the Cardinals' program.