The Raiders (3-6), who trailed 31-26 at halftime, got no closer than nine points the rest of the way and have lost three in a row.
Azotam had 12 points and Jackson 11, and both had 10 rebounds for the Bobcats, who out-rebounded Colgate 46-34.
Quinnipiac also had a lot more chances at the free-throw line, making 25 of 38 to the Raiders' 10 of 15.
Purdue coach Matt Painter says players haven't used the fifth-year graduate transfer rule for its true intent.
The dust has settled after players made their NBA draft decisions. Which college teams won? Which lost? Well, Villanova is pretty happy. USC, meanwhile, might not be as thrilled.
The 2017 recruiting class is short on point guards, with Trevon Duval leading only eight prospects from the ESPN 60 who are still available.