Hines and Simon hit three 3-pointers apiece. Jordan Clarke added nine points and 11 rebounds for the Bulldogs (4-4), who went ahead for good, 31-29, on Richard Carter's layup 2:20 before halftime and led by as many as 16 in the second half.
Frank Gaines, who came in averaging 19.2 points per game, had a game-high 27 on 8-of-17 shooting for the Mastodons (5-6), and Michael Kibiloski chipped in 10 points off the bench. IPFW shot just 36 percent from the floor and committed 21 turnovers.
Drake never trailed, but IPFW tied it at 29 late in the first half. The Bulldogs, though, closed the half on a 10-0 run before Clarke's layup just after halftime made it 41-29.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.