Brandon Young scored 13 points and Melvin finished with 11 points and three blocks in a game where DePaul led by as many as 41. The Panthers beat the Blue Demons last season.
The Blue Demons held Milwaukee to 25.8 percent shooting and forced 17 turnovers.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.