Brandon Young scored 13 points and Melvin finished with 11 points and three blocks in a game where DePaul led by as many as 41. The Panthers beat the Blue Demons last season.
The Blue Demons held Milwaukee to 25.8 percent shooting and forced 17 turnovers.
Colorado State graduate transfer John Gillon has chosen Syracuse, giving the Orange a potential starter at point guard entering the 2016-17 season.
DeSean Murray, who averaged 20.2 points as a sophomore at Presbyterian, will transfer to Auburn to play for coach Bruce Pearl.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.