The Huskies had an 11-point lead midway through the second half, but the Tigers brought it back to just three points, 67-64, when Christian Williams hit a 3-pointer with 6:12 left.
Wilcox then hit a 3-pointer with 5:45 left to lift the Huskies (6-4).
Suggs, coming off a career-high 24 points Thursday against Seattle University, scored nine of his points in the second half, including nine of the Huskies first 14 points to start the half.
Kelsey Howard had 23 points for the Tigers.
For Jackson State (0-8), this was the eighth of 11 consecutive road games to start the season. This was their closest loss.
The Tigers' first home game will be Jan. 6 against Alcorn State.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.