The Huskies had an 11-point lead midway through the second half, but the Tigers brought it back to just three points, 67-64, when Christian Williams hit a 3-pointer with 6:12 left.
Wilcox then hit a 3-pointer with 5:45 left to lift the Huskies (6-4).
Suggs, coming off a career-high 24 points Thursday against Seattle University, scored nine of his points in the second half, including nine of the Huskies first 14 points to start the half.
Kelsey Howard had 23 points for the Tigers.
For Jackson State (0-8), this was the eighth of 11 consecutive road games to start the season. This was their closest loss.
The Tigers' first home game will be Jan. 6 against Alcorn State.
The guard prospect was one of the top players at the annual Spiece Run N Slam event.
SMU has signed a second player from Australia, 6-foot-11 forward Harry Froling, to a national letter of intent. The Mustangs previously signed guard Tom Wilson from Australia.
There's nothing to suggest the Jayhawks won't end up atop the Big 12 for a 13th season in a row. But what about a return to the Final Four?