UC Irvine (5-6) trailed 23-19 at halftime and was behind by as many as 10. The Anteaters battled back by going on a 22-12 run capped by a pair of free throws by Daman Starring to tie it at 44 with 5:38 remaining.
After Alex Young tied it at 51 with a jumper, Starring took over, hitting a jumper and a pair of free throws to put UC Irvine out front for good.
Fresno State shot just 25.5 percent from the field and was 3 of 16 from the arc but did make 20 of 24 from the free-throw line and forced 18 Anteater turnovers.
College basketball fans should be excited about next season's Jimmy V Classic, an event that will feature Duke's heralded freshman class.
Jeff Goodman logs all the coaching changes following the 2015-16 college basketball season.
Can Josh Pastner keep top talent in Georgia? Will Tubby Smith change his recruiting philosophy at Memphis? New coaches face some difficult questions.