UC Irvine (5-6) trailed 23-19 at halftime and was behind by as many as 10. The Anteaters battled back by going on a 22-12 run capped by a pair of free throws by Daman Starring to tie it at 44 with 5:38 remaining.
After Alex Young tied it at 51 with a jumper, Starring took over, hitting a jumper and a pair of free throws to put UC Irvine out front for good.
Fresno State shot just 25.5 percent from the field and was 3 of 16 from the arc but did make 20 of 24 from the free-throw line and forced 18 Anteater turnovers.
Authorities say former Michigan State basketball player Keith Appling has been charged with carrying a concealed weapon and other crimes.
Point guard Jaylen Fisher, who reopened his recruitment after coaching changes at UNLV, has committed to TCU over a long list of schools.
Forward Kennedy Meeks, who has averaged 9.4 points and 6.5 rebounds at North Carolina, has pulled out of the NBA draft and will return to the Tar Heels.