Neil Watson had 15 points and Jerrald Brooks 12 for the Golden Eagles (7-3), who snapped a three-game losing streak.
Terry Rose led Grambling State (0-8) with 18 points. The Tigers have played all their games on the road.
Holding an 11-7 lead 3:48 into the game, the Golden Eagles scored 19 consecutive points and rolled to a 50-21 halftime advantage.
Southern Miss shot 59.6 percent from the field (34 of 57) to Grambling's 32.6 percent (15 of 46) and outscored the Tigers 18-6 from the foul line. Southern Miss outrebounded Grambling 36-23.
Southern Miss won the only other meeting between the teams, a 70-52 victory in the Super Chevy Shootout in Iowa City, Iowa, during the 1996-97 season.
Florida guard Brandone Francis-Ramirez has decided to leave the team after two seasons.
Oklahoma basketball coach Lon Kruger has hired Carlin Hartman as an assistant.
Authorities say former Michigan State basketball player Keith Appling has been charged with carrying a concealed weapon and other crimes.
|Texas San Antonio||3-15||13||5-27|