Neil Watson had 15 points and Jerrald Brooks 12 for the Golden Eagles (7-3), who snapped a three-game losing streak.
Terry Rose led Grambling State (0-8) with 18 points. The Tigers have played all their games on the road.
Holding an 11-7 lead 3:48 into the game, the Golden Eagles scored 19 consecutive points and rolled to a 50-21 halftime advantage.
Southern Miss shot 59.6 percent from the field (34 of 57) to Grambling's 32.6 percent (15 of 46) and outscored the Tigers 18-6 from the foul line. Southern Miss outrebounded Grambling 36-23.
Southern Miss won the only other meeting between the teams, a 70-52 victory in the Super Chevy Shootout in Iowa City, Iowa, during the 1996-97 season.
Purdue coach Matt Painter says players haven't used the fifth-year graduate transfer rule for its true intent.
The dust has settled after players made their NBA draft decisions. Which college teams won? Which lost? Well, Villanova is pretty happy. USC, meanwhile, might not be as thrilled.
The 2017 recruiting class is short on point guards, with Trevon Duval leading only eight prospects from the ESPN 60 who are still available.
|Texas San Antonio||3-15||13||5-27|