The Greyhounds, who play in Division II, led in the first minute of the game. BYU used a 16-2 run to pull away from an 11-all tie, and It was 44-29 at halftime.
Rodney Blackmon led Eastern New Mexico (5-6) with 14 points.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.