The 49ers (11-1) have won two straight since losing to Miami 77-46 on Dec. 14.
Charlotte led 23-6 in the first 10 minutes and 38-19 at halftime as the 49ers shot 56.7 percent from the field (17 of 30) compared to just 26.7 percent (8 of 30) for the Highlanders.
Radford (5-6) got within 12 points twice, at 57-45 with 7:59 remaining and 62-50 with 3:13 to go, but could get no closer.
Chris Braswell, who came in leading the 49ers in scoring (13.4 points a game) and rebounding (6.9), was held to only five points and three boards.
The 49ers, who are 42-8 all-time against Big South Conference teams, outscored the Highlanders 50-28 in the paint.
Javonte Green's 16 points led Radford.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.
|Texas San Antonio||3-15||13||5-27|