The 49ers (11-1) have won two straight since losing to Miami 77-46 on Dec. 14.
Charlotte led 23-6 in the first 10 minutes and 38-19 at halftime as the 49ers shot 56.7 percent from the field (17 of 30) compared to just 26.7 percent (8 of 30) for the Highlanders.
Radford (5-6) got within 12 points twice, at 57-45 with 7:59 remaining and 62-50 with 3:13 to go, but could get no closer.
Chris Braswell, who came in leading the 49ers in scoring (13.4 points a game) and rebounding (6.9), was held to only five points and three boards.
The 49ers, who are 42-8 all-time against Big South Conference teams, outscored the Highlanders 50-28 in the paint.
Javonte Green's 16 points led Radford.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.
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