O'Neale was 5 of 7 from the field, while Griffin was 3 of 5 and had four rebounds.
Southern Utah had a one point lead early in the first half, but Denver (4-6) led 40-20 at halftime and never looked back. The Pioneers shot 55 percent from the field for the game, while the Thunderbirds shot 40.8 percent.
This was the third-straight home win for the Pioneers.
Florida State's student government has passed a resolution discouraging Seminoles fans from wearing Native American headdresses at games.
The second annual Gavitt Tipoff Games, eight games between members of the Big East and Big Ten to be played Nov. 14-18, will feature Villanova at Purdue in the opener.
Michael Lewis is leaving his assistant coaching job at Butler to take the same position at Nebraska under Tim Miles.