Brandon Taylor and D.J. Newbill added 10 points each for the Nittany Lions (7-4), who used a 32-5 first-half run to open a commanding 34-8 lead against the Wildcats (4-7), of the America East Conference.
Penn State, of the Big Ten Conference, has won three straight and is 6-1 at home.
New Hampshire shot just 17.9 percent (5 of 28) in the first half, enabling Penn State to open a 39-14 halftime lead. The Nittany Lions shot 55.2 percent (16 of 29) before halftime, with Taylor scoring all 10 of his points.
Penn State continued to widen its lead in the second half as Marshall scored eight points and New Hampshire was unable to come back with 28 percent second-half shooting (7 of 25).
Penn State surpassed 70 points for the third straight game. Newbill, the sophomore point guard, has scored 10 points or more in 10 of the team's 11 games.
The Nittany Lions' lead reached 52-26 on a jumper by Ross Travis after Donovon Jack blocked a shot by New Hampshire's Chandler Rhoads. Penn State extended the margin to 64-32 as nine of the team's 12 players scored at least three points.
Travis, usually a starter for the Nittany Lions, sprained a knee in practice Thursday but was able to play with a brace. He came off the bench and scored four points and had six rebounds in 21 minutes.
Dillon Brooks, who led Oregon with 16.7 points per game last season, will opt out of the NBA draft process and return to the Ducks, a source told ESPN.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.