Glenn Bryant added 13 points for Eastern Michigan (7-5). The Eagles scored the first 14 points, finished 33 of 60 from the field and limited the NAIA Saints (4-11) to 17-of-53 shooting.
Ryan Hopson led Siena Heights with 11 points.
Eastern Michigan will return to action Wednesday at Kentucky.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.
Jeff Goodman logs all the coaching changes following the 2015-16 college basketball season.
Indiana guard James Blackmon Jr., who averaged 15.8 points in 13 games before being injured last season, has withdrawn from the NBA draft.