The Red Wolves (8-5, 2-2) led 28-23 at halftime. South Alabama shot 25 percent (8 for 32) in the first half.
For the Jaguars (6-6, 3-1), Augustine Rubit had a double-double with 20 points and 17 rebounds. Eight of his points came at the free throw line, Rubit going 8 for 12.
Antoine Allen, however, was the only other player in double figures for South Alabama with 11 points.
The Jaguars shot a season-low 27.4 percent (17 of 62) from the field. Arkansas State, meanwhile, was 21 for 55 (38.2 percent). South Alabama was abysmal from 3-point range, making just 4 of 27 beyond the arc. Allen was 1 for 10 on 3-pointers, Freddie Goldstein 1 for 9.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.
Gonzaga center Przemek Karnowski, who missed most of last season with a back injury, says he is returning for another year.
Wisconsin forward Nigel Hayes has withdrawn from the NBA draft and will return to the Badgers for his senior season.