Tyrone Garland added 15 points and Jerrell Wright posted a double-double with 10 points and 11 rebounds for the Explorers (10-3), who are now 2-0 this season against Big 5 foes. La Salle also beat Villanova 77-74 in overtime on Nov. 25.
Leading 17-16, the Explorers launched a 15-2 run, with Garland hitting three 3-pointers and scoring 11 points in the spurt.
La Salle, which led by as many as 24 in the second half, hit 9 of 22 from long range in its final game before starting Atlantic 10 Conference play.
Mike Krzyzewski says he has good reason to be excited for next season thanks to a combination of Duke's incoming freshmen and a core of experienced upperclassmen.
Georgia guard Juwan Parker has been awarded a medical redshirt, leaving him with two years of eligibility, after missing the 2015-16 season with a partially torn Achilles tendon.
Forward Trevon Bluiett has withdrawn from consideration from the NBA draft and will return to Xavier for his junior season.