Saddler, the league's leading scorer at 19.8 points per game, scored 23 on 9-of-14 shooting, while Threatt had 19 points, made 7 of 13 shots and came up with six steals. Kyle Anderson added 11 points.
The Blue Hens (7-8, 2-0) pulled away with a 16-3 run early in the second half that gave them a 47-33 lead with 13:25 remaining, and they never led by fewer than 11 points the rest of the way.
Daquan Brown came off the bench to score 13 points for the Pride (4-11, 1-1), the only Hofstra player to score in double figures.
Stephen Nwaukoni had 11 rebounds for Hofstra, which beat Georgia State 52-50 Monday night to end an eight-game losing streak.
Maryland point guard Melo Trimble has withdrawn from the NBA draft and will return to College Park for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.